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No long-term human safety data: The absence of evidence of harm is not evidence of absence
What Is Oral Semaglutide
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Some recommend maintaining the highest tolerated dose to prevent weight regain, while others support gradual reduction with close monitoring and lifestyle changes
The usual starting dose of Trulicity is 0.75 mg
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Three MARA domains are material: Clinical Effectiveness (exceptional efficacy, unresolved cardiovascular safety signal), Comparator Selection (retatrutide will be assessed against tirzepatide, not placebo), and HRQoL (higher side effect burden may narrow access relative to established alternatives)
